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clv101
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Post by clv101 »

Ludwig wrote:To return to the point: my understand is that, in general, anything that places stress on the body accelerates the ageing process. Moderate exercise does not count as stress, but regular vigorous, high-impact exercise does.
This is maybe the crux of the matter, you say "Moderate exercise does not count as stress, but regular vigorous, high-impact exercise does."

Well, that's pretty subjective. These days I can run 5 miles in 45 minutes with my heart rate only around 150. That can only be described as moderate, I can easily hold a conversation. Five years ago I wasn't fit enough to run 5 five miles without stopping even at maximum effort with a heart rate close to 200, it would been beyond vigorous.

One man's moderate is another man's vigorous.

Are your definitions of moderate and vigorous relative to your experience of life? Or of the African hunter gathers who evolved the bodies we're currently using for us? I suspect even keen amateur runners in the UK, those clocking up 20-40 miles a week say, would be considered positively sluggish in comparison to the amount of miles our ancestors clocked up.

In the last few generations out of tens of thousands of generations our physical activity has crashed catastrophically. Our bodies are not evolved to spend 10+ hrs a day sitting down. It is far more likely we are evolved to spent 10+ hrs a day on our feet, walking and running. Even keen amateur runners in the UK still spend a lot of time sitting down and only run for a few hours a week - that's nothing compared to our evolutionary history.

Sure, I expect there is a level of activity that damages the body over time. I just think it very high, 100 mile per week territory (which is still only 2hrs running per day). This distances even keen amateurs clock up are considerably below this.
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Post by fifthcolumn »

Ludwig wrote:I seem to recall that the [aging] process is fundamentally linked with the degradation of mitochondria, the parts of the cell that "breathe" oxygen. I think there's a theory that there is an absolute limit on the human lifespan of about 120 years, because degradation of the mitochondria is inevitable given the presence in the human body of oxygen free radicals. Marketing people would have us believe that oxygen free radicals can be harmlessly neutralised using antioxidants, but this is bollocks: free radicals are so reactive that you'd have to overdose on antioxidants to mop them up before they damaged your cells. Anyway, I digress...
Incomplete picture. If it were mopping up free radicals alone then yes.
But in truth it's a balance. There are two systems involved. One is the mopping up of free radicals before they do damage, the other is repairing the damage after it's done.

It seems to be that the repair system slows down as we age until the accumulated damage is so great the repair system effectively stops working.

The way to turn it on again is starvation.....

:shock:
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Ludwig
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Post by Ludwig »

fifthcolumn wrote:
Incomplete picture. If it were mopping up free radicals alone then yes.
But in truth it's a balance. There are two systems involved. One is the mopping up of free radicals before they do damage, the other is repairing the damage after it's done.

It seems to be that the repair system slows down as we age until the accumulated damage is so great the repair system effectively stops working.

The way to turn it on again is starvation.....

:shock:
Thanks. I read a book about this a few years ago ("Oxygen" by Nick Lane - highly recommended) but can't remember all the detail!
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Post by RenewableCandy »

I've also heard a rumour that at extreme distances women are better runners than men, but never looked into whether that is true and, if so, why.
Not sure, but I've heard the same about swiming: lots of successful channel swimmers are women. I think it's to do with the ratio of different types of fat, and how they burn, rather than shape and build.
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clv101
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Post by clv101 »

Yeah, when you get into the 30-40 mile plus range women are just as fast (though fewer enter than men).
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